Significance: Statistical or Clinical?

Statistical significance and clinical significance.

The clinical significance of statistical significance.

Modern clinical trials provide the evidence for most therapeutic advances, and that evidence, expressed in a statistical format, is used to draw inferences about a population from the study's results. Clinician judgment translates these inferences for best individual patient care, but many clinicians struggle with the statistical interpretation of trial results. This review provides a clinical ...

Statistical Significance versus Clinical Significance in Clinical Trials

Clinical trials in cardiovascular medicine: are we looking for statistical significance or clinical relevance?

During the last two decades several large clinical trials have documented beneficial eVects of diVerent pharmacological interventions on morbidity and mortality in various cardiovascular conditions. Based on the results of these trials physicians in general feel convinced that there is a considerable reduction of mortality and morbidity as a result of treatment with: (a) â receptor blockers in ...

Determining clinical significance independently from statistical significance? Implications for practice

Background In science, statistics are universally used for making an inference about a population from sample data. The purpose of statistical inference is to determine if a proposed null hypothesis can be rejected, by comparing the probability of an observation to occur under the null hypothesis (p-value) to a chosen alpha level of confidence. The null hypothesis is rejected if the p-value is ...